Three pericentric inversions on chromosome 2 were isolated following radiation treatment which reduced crossing over between the 2 morphological mutants E and Rs (27-37 map units apart). One inversion, In(2) I, had only 2.2% crossovers between these markers while In(2) 2 and In(2) 3 reduced recombination to 5.9 and 6.7% respectively. The latter 2 inversions (possibly identical) were made homozygous, and both males and females were fertile, In(2) I appears to be lethal when homozygous. A scheme employing these inversions to detect additional mutations (visible and lethal) on chromosome 2 is presented.