A survey for larval and adult Anopheles mosquitoes was conducted in Toledo District of southern Belize during August-September 1992. We surveyed for larvae in 145 habitats and conducted paired indoor-outdoor collections of adult mosquitoes landing on humans at 6 houses. In 1940-41, Kumm and Ram reported Anopheles darlingi females to be the most common Anopheles mosquitoes inside houses and reported no specimens of Anopheles vestitipennis in southern Belize. In our 1992 survey we found no An. darlingi mosquitoes either as adults or larvae. More An. vestitipennis females were captured indoors than outdoors, whereas most Anopheles albimanus and Anopheles apicimacula females were captured outdoors. All 3 species were represented occasionally in 145 collections of larvae from diverse habitats. Anopheles vestitipennis now appears to be a potentially important vector of malaria during the wet season in Toledo District. Other Abstract Kumm and Ram surveyed for the presence of larval and adult Anopheles mosquitoes in Belize in 1940-41.They found An. darlingi to be the most common of Anopheles species inside houses and reported observing no An. vestitipennis in southern Belize.That study was conducted before the DDT malaria control program was implemented in the country and offers the most recent publication of such findings for the area up to the publication of this more recent report by the authors.The authors report findings from a recent survey of larval and adult Anopheles mosquitoes in the Toledo District during August-September 1992.The presence of larvae was surveyed in 145 habitats, while paired indoor-outdoor collections of adult mosquitoes landing on humans were taken at six houses.The authors, however, report finding no An. darlingi mosquitoes, either as adults or larvae.More An. vestitipennis females were captured indoors than outdoors and most An. albimanus and An. apicimacula females were captured outdoors.All three species were represented occasionally in the collections of larvae from diverse habitats.These findings clearly suggest that An. vestitipennis is a potentially important vector of malaria in the wet season in Toledo District.